InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HS2ST1

Summary

InnateDB Protein

IDBP-100112.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HS2ST1

Protein Name

heparan sulfate 2-O-sulfotransferase 1

Synonyms

dJ604K5.2;

Species

Homo sapiens

Ensembl Protein

ENSP00000359581

InnateDB Gene

IDBG-100108 (HS2ST1)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0008152	metabolic process
GO:0030203	glycosaminoglycan metabolic process
GO:0044281	small molecule metabolic process