InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF2B

Summary

InnateDB Protein

IDBP-100142.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF2B

Protein Name

general transcription factor IIB

Synonyms

TF2B; TFIIB;

Species

Homo sapiens

Ensembl Protein

ENSP00000359531

InnateDB Gene

IDBG-100140 (GTF2B)

Protein Structure

UniProt Annotation

Function

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	98 [view]
Protein-Protein	88 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0017025	TBP-class protein binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000812 Transcription factor TFIIB
IPR006671 Cyclin, N-terminal
IPR013137 Zinc finger, TFIIB-type
IPR013150 Transcription factor TFIIB, cyclin-like domain
IPR013763 Cyclin-like

PFAM

PF00134
PF08271
PF00382

PRINTS

PR00685

PIRSF

SMART

SM00385

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt