Version 5.4
Homo sapiens Protein: GBP7
Summary
InnateDB Protein IDBP-100176.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GBP7
Protein Name guanylate binding protein 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000294671
InnateDB Gene IDBG-241226 (GBP7)
Protein Structure
UniProt Annotation
Function Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR003191 Guanylate-binding protein, C-terminal
IPR015894 Guanylate-binding protein, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF02841
PF02263
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N8V2
PhosphoSite PhosphoSite-Q8N8V2
TrEMBL
UniProt Splice Variant
Entrez Gene 388646
UniGene Hs.630435
RefSeq NP_997281
HUGO HGNC:29606
OMIM 612468
CCDS CCDS720
HPRD 13432
IMGT
EMBL AC104459 AK096141
GenPept BAC04709

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca