Version 5.4
Homo sapiens Protein: ZNF326
Summary
InnateDB Protein IDBP-100207.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF326
Protein Name zinc finger protein 326
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355318
InnateDB Gene IDBG-100201 (ZNF326)
Protein Structure
UniProt Annotation
Function Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. {ECO:0000269PubMed:22446626}.
Subcellular Localization Nucleus matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000993 RNA polymerase II core binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0032784 regulation of DNA-templated transcription, elongation
Cellular Component
GO:0005681 spliceosomal complex
GO:0016363 nuclear matrix
GO:0044609 DBIRD complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5BKZ1
PhosphoSite PhosphoSite-Q5BKZ1
TrEMBL
UniProt Splice Variant
Entrez Gene 284695
UniGene Hs.604906
RefSeq NP_892020
HUGO HGNC:14104
OMIM 614601
CCDS CCDS728
HPRD 15774
IMGT
EMBL AK297073 AK303707 AL161797 AL391497 BC052645 BC053888 BC070341 BC090866 CH471097
GenPept AAH52645 AAH53888 AAH70341 AAH90866 BAG59592 BAG64691 CAH72228 CAH72229 CAH72230 CAI23073 CAI23074 EAW73125 EAW73128

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca