InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP29

Summary

InnateDB Protein

IDBP-100368.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP29

Protein Name

Rho GTPase activating protein 29

Synonyms

PARG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000260526

InnateDB Gene

IDBG-100366 (ARHGAP29)

Protein Structure

UniProt Annotation

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269PubMed:15752761, ECO:0000269PubMed:9305890}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney. {ECO:0000269PubMed:9305890}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035556	intracellular signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR008936 Rho GTPase activation protein

PFAM

PF00620
PF00130

PRINTS

PIRSF

SMART

SM00324
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q52LW3