InnateDB Protein
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IDBP-100372.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARHGAP29
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Protein Name
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Rho GTPase activating protein 29
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Synonyms
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PARG1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359237
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InnateDB Gene
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IDBG-100366 (ARHGAP29)
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Protein Structure
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Function |
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269PubMed:15752761, ECO:0000269PubMed:9305890}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney. {ECO:0000269PubMed:9305890}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0007264
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small GTPase mediated signal transduction
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GO:0007266
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Rho protein signal transduction
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GO:0032321
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positive regulation of Rho GTPase activity
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GO:0051056
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regulation of small GTPase mediated signal transduction
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q52LW3
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PhosphoSite |
PhosphoSite-Q52LW3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9411
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UniGene |
Hs.664491
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RefSeq |
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HUGO |
HGNC:30207
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OMIM |
610496
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CCDS |
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HPRD |
06674
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IMGT |
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EMBL |
AB208873
AL162735
BC022483
BC067839
BC093741
BC093767
CH471097
U90920
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GenPept |
AAB81012
AAH22483
AAH67839
AAH93741
AAH93767
BAD92110
CAH71750
CAH71751
EAW73051
EAW73052
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