Version 5.4
Homo sapiens Protein: CNN3
Summary
InnateDB Protein IDBP-100390.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNN3
Protein Name calponin 3, acidic
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359225
InnateDB Gene IDBG-100388 (CNN3)
Protein Structure
UniProt Annotation
Function Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in both non-smooth muscle tissues as well as smooth muscle tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0030855 epithelial cell differentiation
GO:0031032 actomyosin structure organization
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID
InterPro IPR000557 Calponin repeat
IPR001715 Calponin homology domain
IPR001997 Calponin
IPR003096 Smooth muscle protein/calponin
PFAM PF00402
PF00307
PRINTS PR00889
PR00888
PIRSF
SMART SM00033
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15417
PhosphoSite PhosphoSite-Q15417
TrEMBL Q9BWY6
UniProt Splice Variant
Entrez Gene 1266
UniGene Hs.483454
RefSeq NP_001830
HUGO HGNC:2157
OMIM 602374
CCDS CCDS30775
HPRD 03848
IMGT
EMBL AC093429 AC105942 AK294141 AK298145 AK312370 AK316398 AL359554 BC025372 CH471097 CR541848 S80562
GenPept AAB35752 AAH25372 BAG35288 BAG57467 BAG60421 BAH14769 CAC36092 CAC36093 CAG46646 EAW73029

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca