Homo sapiens Protein: SLC25A24 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-100658.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | SLC25A24 | ||||||||||||||||||
Protein Name | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000359058 | ||||||||||||||||||
InnateDB Gene | IDBG-100654 (SLC25A24) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress- induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix. {ECO:0000269PubMed:15123600, ECO:0000269PubMed:22015608}. | ||||||||||||||||||
Subcellular Localization | Mitochondrion inner membrane {ECO:0000269PubMed:15054102, ECO:0000269PubMed:15123600, ECO:0000269PubMed:22015608}; Multi-pass membrane protein {ECO:0000269PubMed:15054102, ECO:0000269PubMed:15123600, ECO:0000269PubMed:22015608}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Present in various cell lines (at protein level). Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart. {ECO:0000269PubMed:15054102, ECO:0000269PubMed:15123600}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR002048
EF-hand domain IPR002067 Mitochondrial carrier protein IPR002167 Graves disease carrier protein IPR018108 Mitochondrial substrate/solute carrier IPR023395 Mitochondrial carrier domain |
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PFAM |
PF00036
PF13202 PF13405 PF00153 |
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PRINTS |
PR00926
PR00928 |
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PIRSF | |||||||||||||||||||
SMART |
SM00054
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q6NUK1 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q6NUK1 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 29957 | ||||||||||||||||||
UniGene | Hs.656870 | ||||||||||||||||||
RefSeq | NP_998816 | ||||||||||||||||||
HUGO | HGNC:20662 | ||||||||||||||||||
OMIM | 608744 | ||||||||||||||||||
CCDS | CCDS786 | ||||||||||||||||||
HPRD | 12290 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF123303 AJ619961 AJ619987 AK292567 AK316304 AL359258 AL390036 BC014519 BC068561 CH471156 | ||||||||||||||||||
GenPept | AAF28888 AAH14519 AAH68561 BAF85256 BAH14675 CAF04058 CAF04493 CAI13622 CAI13623 CAI14512 CAI14513 EAW51254 EAW51255 | ||||||||||||||||||