Version 5.4
Homo sapiens Protein: OLFML3
Summary
InnateDB Protein IDBP-101276.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OLFML3
Protein Name olfactomedin-like 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000322273
InnateDB Gene IDBG-101274 (OLFML3)
Protein Structure
UniProt Annotation
Function Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes. {ECO:0000250, ECO:0000269PubMed:15280020}.
Subcellular Localization Secreted {ECO:0000269PubMed:15280020}.
Disease Associations
Tissue Specificity Abundant in placenta, moderate in liver and heart, whereas fairly weak in other tissues examined. On term placenta, mainly localized extracellularly surrounding the syncytiotrophoblastic cells and very rarely expressed in the maternal decidua layer. {ECO:0000269PubMed:15280020}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR003112 Olfactomedin-like
PFAM PF02191
PRINTS
PIRSF
SMART SM00284
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRN5
PhosphoSite PhosphoSite-Q9NRN5
TrEMBL M1LAK4
UniProt Splice Variant
Entrez Gene 56944
UniGene Hs.9315
RefSeq NP_064575
HUGO HGNC:24956
OMIM 610088
CCDS CCDS870
HPRD 14878
IMGT
EMBL AF201945 AK075353 AK075479 AK075544 AK222471 AK223221 AK297902 AL731797 AY358954 AY464015 BC009920 CH471122 KC237062
GenPept AAF86881 AAH09920 AAQ89313 AAR88262 AGF36554 BAC11564 BAC11644 BAC11687 BAD96191 BAD96941 BAG60222 CAI22797 CAI22798 EAW56595

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca