InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSDE1

Summary

InnateDB Protein

IDBP-101316.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSDE1

Protein Name

cold shock domain containing E1, RNA-binding

Synonyms

D1S155E; UNR;

Species

Homo sapiens

Ensembl Protein

ENSP00000261443

InnateDB Gene

IDBG-101304 (CSDE1)

Protein Structure

UniProt Annotation

Function

RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain. {ECO:0000269PubMed:11051545, ECO:0000269PubMed:15314026}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	27 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0008584	male gonad development
GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0070937	CRD-mediated mRNA stability complex

Protein Structure and Domains

PDB ID

InterPro

IPR002059 Cold-shock protein, DNA-binding
IPR011129 Cold shock protein
IPR012340 Nucleic acid-binding, OB-fold

PFAM

PF00313

PRINTS

PR00050

PIRSF

SMART

SM00357

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75534

PhosphoSite

PhosphoSite-O75534

TrEMBL

Q9UG93

UniProt Splice Variant

Entrez Gene

7812

UniGene

Hs.737558

RefSeq

NP_001229822

HUGO

HGNC:29905

OMIM

191510

CCDS

CCDS30811

HPRD

15949

IMGT

EMBL

AB020692 AF070542 AF077054 AK290146 AL050150 AL096773 BC032446 CH471122 CR749378 CR749431

GenPept

AAC28634 AAD27787 AAH32446 BAA74908 BAF82835 CAB43294 CAH18231 CAH18269 CAI18825 CAI18826 EAW56612 EAW56613 EAW56616 EAW56618 EAW56619