InnateDB Protein
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IDBP-101321.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SIKE1
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Protein Name
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suppressor of IKBKE 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000358541
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InnateDB Gene
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IDBG-101319 (SIKE1)
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Protein Structure
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Function |
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways. {ECO:0000269PubMed:16281057}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16281057}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level). {ECO:0000269PubMed:16281057}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
39
[view]
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Protein-Protein |
39
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008555
Suppressor of IKBKE 1
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PFAM |
PF05769
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BRV8
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PhosphoSite |
PhosphoSite-Q9BRV8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80143
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UniGene |
Hs.709277
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RefSeq |
NP_001095866
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HUGO |
HGNC:26119
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OMIM |
611656
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CCDS |
CCDS41371
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HPRD |
07958
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IMGT |
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EMBL |
AK024821
AL096773
BC005934
CH471122
CR749219
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GenPept |
AAH05934
BAB15020
CAH18076
CAI18822
CAI18823
CAI18824
EAW56620
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