InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUOX2

Summary

InnateDB Protein

IDBP-10158.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUOX2

Protein Name

dual oxidase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000373691

InnateDB Gene

IDBG-10041 (DUOX2)

Protein Structure

UniProt Annotation

Function

Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269PubMed:12824283}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:15591162}; Multi-pass membrane protein {ECO:0000269PubMed:15591162}. Note=Localizes to the apical membrane of epithelial cells.

Disease Associations

Thyroid dyshormonogenesis 6 (TDH6) [MIM:607200]: A disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. {ECO:0000269PubMed:12110737, ECO:0000269PubMed:16134168, ECO:0000269PubMed:16322276, ECO:0000269PubMed:20187165}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis. {ECO:0000269PubMed:10806195, ECO:0000269PubMed:11514595, ECO:0000269PubMed:12824283, ECO:0000269PubMed:15210697, ECO:0000269PubMed:15591162}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005509	calcium ion binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding

Biological Process

GO:0006979	response to oxidative stress
GO:0045087	innate immune response (InnateDB)
GO:0055114	oxidation-reduction process

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain
IPR010255 Haem peroxidase
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel
IPR019791 Haem peroxidase, animal

PFAM