Version 5.4
Homo sapiens Protein: GOLPH3L
Summary
InnateDB Protein IDBP-102175.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GOLPH3L
Protein Name golgi phosphoprotein 3-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000271732
InnateDB Gene IDBG-102171 (GOLPH3L)
Protein Structure
UniProt Annotation
Function Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. {ECO:0000269PubMed:23345592}.
Subcellular Localization Golgi apparatus, Golgi stack membrane {ECO:0000269PubMed:23345592}; Peripheral membrane protein {ECO:0000269PubMed:23345592}; Cytoplasmic side {ECO:0000269PubMed:23345592}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:23345592}; Peripheral membrane protein {ECO:0000269PubMed:23345592}; Cytoplasmic side {ECO:0000269PubMed:23345592}. Note=Phosphatidylinositol 4- phosphate (PtdIns4P)-binding mediates recruitment to Golgi membranes.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0070273 phosphatidylinositol-4-phosphate binding
Biological Process
GO:0007030 Golgi organization
GO:0050714 positive regulation of protein secretion
Cellular Component
GO:0000139 Golgi membrane
GO:0032580 Golgi cisterna membrane
GO:0032588 trans-Golgi network membrane
Protein Structure and Domains
PDB ID
InterPro IPR008628 Golgi phosphoprotein 3
PFAM PF05719
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H4A5
PhosphoSite PhosphoSite-Q9H4A5
TrEMBL
UniProt Splice Variant
Entrez Gene 55204
UniGene Hs.740573
RefSeq NP_060648
HUGO HGNC:24882
OMIM 612208
CCDS CCDS966
HPRD 17048
IMGT
EMBL AJ296153 AK001549 AK300635 AK315594 AL356292 AL356356 BC013870 CH471121
GenPept AAH13870 BAA91750 BAG37966 BAH13319 CAC13125 CAI13650 CAI15495 EAW53526

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca