InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNAPIN

Summary

InnateDB Protein

IDBP-102761.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNAPIN

Protein Name

SNAP-associated protein

Synonyms

BLOC1S7; BLOS7; SNAPAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000357674

InnateDB Gene

IDBG-102759 (SNAPIN)

Protein Structure

UniProt Annotation

Function

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma- membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. {ECO:0000269PubMed:17182842, ECO:0000269PubMed:18167355}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269PubMed:18167355, ECO:0000269PubMed:19168546, ECO:0000269PubMed:21102408}. Golgi apparatus membrane {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=May be cytoplasmic and peripheral membrane bound or anchored to the vesicular membrane through an N- terminal signal anchor (By similarity). Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in male germ cells of adult testis (at protein level). {ECO:0000269PubMed:19168546}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0008089	anterograde axon cargo transport
GO:0010977	negative regulation of neuron projection development
GO:0016032	viral process
GO:0016079	synaptic vesicle exocytosis
GO:0016188	synaptic vesicle maturation
GO:0031175	neuron projection development
GO:0031629	synaptic vesicle fusion to presynaptic membrane
GO:0032438	melanosome organization
GO:0043393	regulation of protein binding
GO:0048489	synaptic vesicle transport
GO:0048490	anterograde synaptic vesicle transport
GO:0072553	terminal button organization
GO:1902824	positive regulation of late endosome to lysosome transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005730	nucleolus
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030133	transport vesicle
GO:0030141	secretory granule
GO:0030659	cytoplasmic vesicle membrane
GO:0030672	synaptic vesicle membrane
GO:0031083	BLOC-1 complex
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm