Version 5.4
Homo sapiens Protein: GATAD2B
Summary
InnateDB Protein IDBP-102797.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GATAD2B
Protein Name GATA zinc finger domain containing 2B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357644
InnateDB Gene IDBG-102795 (GATAD2B)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. {ECO:0000269PubMed:12183469, ECO:0000269PubMed:16415179}.
Subcellular Localization Nucleus speckle {ECO:0000269PubMed:11756549, ECO:0000269PubMed:12183469, ECO:0000269PubMed:16415179}. Note=Speckled nuclear localization requires both CR1 and CR2 regions.
Disease Associations Mental retardation, autosomal dominant 18 (MRD18) [MIM:615074]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD18 patients have severe intellectual disability and dysmorphic features. {ECO:0000269PubMed:23033978, ECO:0000269PubMed:23644463}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12183469}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031492 nucleosomal DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043044 ATP-dependent chromatin remodeling
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR000679 Zinc finger, GATA-type
PFAM PF00320
PRINTS PR00619
PIRSF
SMART SM00401
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXI9
PhosphoSite PhosphoSite-Q8WXI9
TrEMBL
UniProt Splice Variant
Entrez Gene 57459
UniGene Hs.596854
RefSeq NP_065750
HUGO HGNC:30778
OMIM 614998
CCDS CCDS1054
HPRD 15094
IMGT
EMBL AB032976 AF411836 AL513523 BC069419 BC112052 BC112080 CH471121
GenPept AAH69419 AAI12053 AAI12081 AAL39080 BAA86464 CAH71425 EAW53270

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca