InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL6R

Summary

InnateDB Protein

IDBP-102947.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL6R

Protein Name

interleukin 6 receptor

Synonyms

CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ;

Species

Homo sapiens

Ensembl Protein

ENSP00000357470

InnateDB Gene

IDBG-102945 (IL6R)

Protein Structure

UniProt Annotation

Function

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.

Subcellular Localization

Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.

Disease Associations

Tissue Specificity

Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004897	ciliary neurotrophic factor receptor activity
GO:0004915	interleukin-6 receptor activity
GO:0005138	interleukin-6 receptor binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019981	interleukin-6 binding
GO:0042803	protein homodimerization activity
GO:0070119	ciliary neurotrophic factor binding

Biological Process

GO:0002384	hepatic immune response
GO:0002446	neutrophil mediated immunity
GO:0002548	monocyte chemotaxis
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0006953	acute-phase response
GO:0008284	positive regulation of cell proliferation
GO:0010536	positive regulation of activation of Janus kinase activity
GO:0019221	cytokine-mediated signaling pathway
GO:0031018	endocrine pancreas development
GO:0032717	negative regulation of interleukin-8 production
GO:0032722	positive regulation of chemokine production
GO:0032755	positive regulation of interleukin-6 production
GO:0032966	negative regulation of collagen biosynthetic process
GO:0034097	response to cytokine
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410	positive regulation of MAPK cascade
GO:0045669	positive regulation of osteoblast differentiation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0070102	interleukin-6-mediated signaling pathway
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005896	interleukin-6 receptor complex
GO:0009986	cell surface
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR015321 Interleukin-6 receptor alpha, binding

PFAM

PF00041
PF01108
PF09240

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08887