Version 5.4
Homo sapiens Protein: FLAD1
Summary
InnateDB Protein IDBP-103039.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLAD1
Protein Name FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357417
InnateDB Gene IDBG-103029 (FLAD1)
Protein Structure
UniProt Annotation
Function Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
Subcellular Localization Isoform 1: Mitochondrion matrix.Isoform 2: Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003919 FMN adenylyltransferase activity
GO:0005524 ATP binding
Biological Process
GO:0006747 FAD biosynthetic process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006771 riboflavin metabolic process
GO:0006777 Mo-molybdopterin cofactor biosynthetic process
GO:0008152 metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001453 Molybdopterin binding domain
IPR002500 Phosphoadenosine phosphosulphate reductase
IPR012183 FAD synthetase, molybdopterin binding
PFAM PF00994
PF01507
PRINTS
PIRSF PIRSF036620
SMART SM00852
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NFF5
PhosphoSite PhosphoSite-Q8NFF5
TrEMBL
UniProt Splice Variant
Entrez Gene 80308
UniGene Hs.118666
RefSeq NP_001171820
HUGO HGNC:24671
OMIM 610595
CCDS CCDS53371
HPRD 17887
IMGT
EMBL AF218022 AF481877 AF520568 AL451085 BC011378 BC014012 BC020253 BC021096 BC032323 CH471121 DQ458779 U79241
GenPept AAB50199 AAG17264 AAH11378 AAH14012 AAH20253 AAH21096 AAH32323 AAM77338 AAO49318 ABE65383 CAI13259 CAI13260 CAI13261 CAI13262 EAW53154 EAW53155 EAW53158 EAW53159

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca