Version 5.4
Homo sapiens Protein: MTX1
Summary
InnateDB Protein IDBP-103185.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTX1
Protein Name metaxin 1
Synonyms MTX; MTXN;
Species Homo sapiens
Ensembl Protein ENSP00000357360
InnateDB Gene IDBG-103181 (MTX1)
Protein Structure
UniProt Annotation
Function Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion outer membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
IPR019564 Mitochondrial outer membrane transport complex, Sam37/metaxin
PFAM PF10568
PF11801
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13505
PhosphoSite PhosphoSite-Q13505
TrEMBL
UniProt Splice Variant
Entrez Gene 4580
UniGene Hs.490874
RefSeq NP_002446
HUGO HGNC:7504
OMIM 600605
CCDS CCDS1100
HPRD 11861
IMGT
EMBL AF023268 AK313863 AL713999 BC001906 CH471121 U46920
GenPept AAC50490 AAC51819 AAH01906 BAG36591 CAI95085 CAI95086 EAW53105

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca