InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MEF2D

Summary

InnateDB Protein

IDBP-103521.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MEF2D

Protein Name

myocyte enhancer factor 2D

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000271555

InnateDB Gene

IDBG-103519 (MEF2D)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00251, ECO:0000269PubMed:12691662, ECO:0000269PubMed:15743823}. Note=Translocated by HDAC4 to nuclear dots.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	39 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0033613	activating transcription factor binding
GO:0042826	histone deacetylase binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0001958	endochondral ossification
GO:0002062	chondrocyte differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007399	nervous system development
GO:0007512	adult heart development
GO:0007517	muscle organ development
GO:0035914	skeletal muscle cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter