InnateDB Protein
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IDBP-103531.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MEF2D
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Protein Name
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myocyte enhancer factor 2D
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000353803
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InnateDB Gene
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IDBG-103519 (MEF2D)
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Protein Structure
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Function |
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00251, ECO:0000269PubMed:12691662, ECO:0000269PubMed:15743823}. Note=Translocated by HDAC4 to nuclear dots.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
41
[view]
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Protein-Protein |
39
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000977
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RNA polymerase II regulatory region sequence-specific DNA binding
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GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0033613
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activating transcription factor binding
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GO:0042826
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histone deacetylase binding
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GO:0046983
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protein dimerization activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002100
Transcription factor, MADS-box
IPR022102
Holliday junction regulator protein family C-terminal
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PFAM |
PF00319
PF12347
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PRINTS |
PR00404
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PIRSF |
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SMART |
SM00432
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TIGRFAMs |
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Modification |
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SwissProt |
Q14814
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PhosphoSite |
PhosphoSite-Q14814
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
4209
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UniGene |
Hs.619220
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RefSeq |
NP_001258558
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HUGO |
HGNC:6997
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OMIM |
600663
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CCDS |
CCDS60304
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HPRD |
02810
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IMGT |
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EMBL |
AL139412
BC040949
BC054520
CH471121
L16794
L16795
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GenPept |
AAA59579
AAA93194
AAH40949
AAH54520
CAI17184
CAI17185
EAW52948
EAW52952
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