InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HAPLN2

Summary

InnateDB Protein

IDBP-103569.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HAPLN2

Protein Name

hyaluronan and proteoglycan link protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000255039

InnateDB Gene

IDBG-103567 (HAPLN2)

Protein Structure

UniProt Annotation

Function

Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed only in adult brain. {ECO:0000269PubMed:11027579}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding

Biological Process

GO:0007155	cell adhesion
GO:0008065	establishment of blood-nerve barrier
GO:0085029	extracellular matrix assembly

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000538 Link
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR016187 C-type lectin fold

PFAM

PF00193
PF07686

PRINTS

PR01265

PIRSF

SMART

SM00445
SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt