InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRP

Summary

InnateDB Protein

IDBP-103913.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRP

Protein Name

C-reactive protein, pentraxin-related

Synonyms

PTX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000255030

InnateDB Gene

IDBG-103911 (CRP)

Protein Structure

UniProt Annotation

Function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Found in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	21 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001849	complement component C1q binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0015485	cholesterol binding
GO:0030169	low-density lipoprotein particle binding
GO:0033265	choline binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0006953	acute-phase response
GO:0006954	inflammatory response
GO:0006958	complement activation, classical pathway
GO:0007568	aging
GO:0008228	opsonization
GO:0010288	response to lead ion
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010888	negative regulation of lipid storage
GO:0042060	wound healing
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0050830	defense response to Gram-positive bacterium
GO:0051258	protein polymerization
GO:0071277	cellular response to calcium ion
GO:1900006	positive regulation of dendrite development