InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAMTS4

Summary

InnateDB Protein

IDBP-104223.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS4

Protein Name

ADAM metallopeptidase with thrombospondin type 1 motif, 4

Synonyms

ADAMTS-2; ADAMTS-4; ADMP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000356975

InnateDB Gene

IDBG-104221 (ADAMTS4)

Protein Structure

UniProt Annotation

Function

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu--Ala-393' site.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001501	skeletal system development
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0042742	defense response to bacterium

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich
IPR010294 ADAM-TS Spacer 1
IPR013273 Peptidase M12B, ADAM-TS

PFAM

PF00090
PF01421
PF01562
PF08516
PF05986

PRINTS

PR01857

PIRSF

SMART

SM00209
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt