InnateDB Protein
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IDBP-104286.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FCGR2A
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Protein Name
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Fc fragment of IgG, low affinity IIa, receptor (CD32)
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Synonyms
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CD32; CD32A; CDw32; FCG2; FcGR; FCGR2; FCGR2A1; IGFR2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356949
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InnateDB Gene
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IDBG-104282 (FCGR2A)
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Protein Structure
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Function |
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. {ECO:0000269PubMed:19011614}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:19011614}; Single-pass type I membrane protein {ECO:0000269PubMed:19011614}.
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Disease Associations |
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Tissue Specificity |
Found on monocytes, neutrophils and eosinophil platelets.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
18
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0038096
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Fc-gamma receptor signaling pathway involved in phagocytosis
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GO:0045087
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innate immune response (InnateDB)
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Cellular Component |
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PDB ID |
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InterPro |
IPR003598
Immunoglobulin subtype 2
IPR003599
Immunoglobulin subtype
IPR007110
Immunoglobulin-like domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00408
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
P12318
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PhosphoSite |
PhosphoSite-P12318
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9103
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UniGene |
Hs.717076
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RefSeq |
NP_067674
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HUGO |
HGNC:3616
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OMIM |
612169
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CCDS |
CCDS30922
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HPRD |
00906
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IMGT |
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EMBL |
AL590385
BC019931
BC020823
J03619
M31932
Y00644
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GenPept |
AAA35827
AAA35932
AAH19931
AAH20823
CAA68672
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