InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSPA6

Summary

InnateDB Protein

IDBP-104289.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPA6

Protein Name

heat shock 70kDa protein 6 (HSP70B')

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000310219

InnateDB Gene

IDBG-104287 (HSPA6)

Protein Structure

UniProt Annotation

Function

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0031072	heat shock protein binding
GO:0042623	ATPase activity, coupled
GO:0051082	unfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006200	ATP catabolic process
GO:0006986	response to unfolded protein
GO:0034605	cellular response to heat
GO:0042026	protein refolding

Cellular Component

GO:0005737	cytoplasm
GO:0005814	centriole
GO:0005829	cytosol
GO:0008180	COP9 signalosome
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P17066