InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPPP

Summary

InnateDB Protein

IDBP-10441.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPPP

Protein Name

tubulin polymerization promoting protein

Synonyms

p24; p25; p25alpha; TPPP/p25; TPPP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000353785

InnateDB Gene

IDBG-10439 (TPPP)

Protein Structure

UniProt Annotation

Function

May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. {ECO:0000269PubMed:17105200, ECO:0000269PubMed:17693641, ECO:0000269PubMed:18028908}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10083737}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding

Biological Process

GO:0001578	microtubule bundle formation
GO:0031334	positive regulation of protein complex assembly
GO:0032273	positive regulation of protein polymerization
GO:0046785	microtubule polymerization