InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BLZF1

Summary

InnateDB Protein

IDBP-104655.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BLZF1

Protein Name

basic leucine zipper nuclear factor 1

Synonyms

GOLGIN-45; JEM-1; JEM-1s; JEM1;

Species

Homo sapiens

Ensembl Protein

ENSP00000356781

InnateDB Gene

IDBG-104649 (BLZF1)

Protein Structure

UniProt Annotation

Function

Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface.

Subcellular Localization

Golgi apparatus lumen {ECO:0000269PubMed:11056056, ECO:0000269PubMed:11739401, ECO:0000269PubMed:9129147}.Isoform 1: Nucleus.Isoform 2: Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous. Also found in cell lines derived from several hematopoietic pathologies, such as T-cell leukemia, pro-B, pre-B, myeloma, and plasmacytoma cell lines, but not in Burkitt lymphoma cells. {ECO:0000269PubMed:11056056, ECO:0000269PubMed:11739401, ECO:0000269PubMed:9129147}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	19 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0001558	regulation of cell growth
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007030	Golgi organization
GO:0008283	cell proliferation
GO:0043001	Golgi to plasma membrane protein transport