InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SELL

Summary

InnateDB Protein

IDBP-104698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SELL

Protein Name

selectin L

Synonyms

CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL; LYAM1; PLNHR; TQ1;

Species

Homo sapiens

Ensembl Protein

ENSP00000236147

InnateDB Gene

IDBG-104696 (SELL)

Protein Structure

UniProt Annotation

Function

Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. {ECO:0000269PubMed:12403782}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in B-cell lines and T-lymphocytes. {ECO:0000269PubMed:2473156}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0030246	carbohydrate binding
GO:0043208	glycosphingolipid binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0033198	response to ATP
GO:0050776	regulation of immune response
GO:0050900	leukocyte migration

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR000742 Epidermal growth factor-like domain
IPR001304 C-type lectin
IPR002396 Selectin superfamily
IPR016187 C-type lectin fold
IPR016348 L-selectin

PFAM

PF00084
PF00008
PF00059

PRINTS

PR00343

PIRSF

PIRSF002421

SMART

SM00032
SM00181
SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References