InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRDX6

Summary

InnateDB Protein

IDBP-104874.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDX6

Protein Name

peroxiredoxin 6

Synonyms

1-Cys; aiPLA2; AOP2; HEL-S-128m; NSGPx; p29; PRX;

Species

Homo sapiens

Ensembl Protein

ENSP00000342026

InnateDB Gene

IDBG-104872 (PRDX6)

Protein Structure

UniProt Annotation

Function

Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16186110, ECO:0000269PubMed:19188445}. Lysosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Also found in lung secretory organelles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.

Experimentally validated
Total	62 [view]
Protein-Protein	62 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004602	glutathione peroxidase activity
GO:0004623	phospholipase A2 activity
GO:0005515	protein binding
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0051920	peroxiredoxin activity

Biological Process

GO:0006979	response to oxidative stress
GO:0009395	phospholipid catabolic process
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
IPR013740 Redoxin
IPR019479 Peroxiredoxin, C-terminal

PFAM