InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHX9

Summary

InnateDB Protein

IDBP-105282.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX9

Protein Name

DEAH (Asp-Glu-Ala-His) box polypeptide 9

Synonyms

DDX9; LKP; NDH2; NDHII; RHA;

Species

Homo sapiens

Ensembl Protein

ENSP00000356520

InnateDB Gene

IDBG-105280 (DHX9)

Protein Structure

UniProt Annotation

Function

Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD- mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Positively regulates HIV-1 LTR-directed gene expression. {ECO:0000269PubMed:19029303, ECO:0000269PubMed:19229320, ECO:0000269PubMed:22190748}.

Subcellular Localization

Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Can shuttle between nucleus and cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 246 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	246 [view]
Protein-Protein	246 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003724	RNA helicase activity
GO:0004003	ATP-dependent DNA helicase activity
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0001649	osteoblast differentiation
GO:0006200	ATP catabolic process
GO:0007623	circadian rhythm
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0032481	positive regulation of type I interferon production
GO:0032508	DNA duplex unwinding
GO:0034605	cellular response to heat
GO:0045087	innate immune response (InnateDB)
GO:0070934	CRD-mediated mRNA stabilization

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0070937	CRD-mediated mRNA stability complex

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR007502 Helicase-associated domain
IPR011545 DEAD/DEAH box helicase domain
IPR011709 Domain of unknown function DUF1605
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014720 Double-stranded RNA-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04408
PF00270
PF07717
PF00035

PRINTS

PIRSF

SMART

SM00490
SM00847
SM00487
SM00358

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08211