InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FAM129A

Summary

InnateDB Protein

IDBP-105368.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAM129A

Protein Name

family with sequence similarity 129, member A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356481

InnateDB Gene

IDBG-105366 (FAM129A)

Protein Structure

UniProt Annotation

Function

Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16949643}.

Disease Associations

Tissue Specificity

Expressed in various types of thyroid tumor such as papillary thyroid carcinomas and oxyphilic thyroid tumors but not in normal thyroid tissue (at protein level). Strongly expressed in heart, skeletal muscle, pancreas, white blood cells and prostate with moderate expression in colon and spleen. Expressed in renal carcinoma cells but not in normal kidney. {ECO:0000269PubMed:11011112, ECO:0000269PubMed:16949643}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0001934	positive regulation of protein phosphorylation
GO:0034976	response to endoplasmic reticulum stress
GO:0045727	positive regulation of translation