Version 5.4
Homo sapiens Protein: B3GALT2
Summary
InnateDB Protein IDBP-105496.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B3GALT2
Protein Name UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
Synonyms beta3Gal-T2; BETA3GALT2; GLCT2;
Species Homo sapiens
Ensembl Protein ENSP00000356404
InnateDB Gene IDBG-105494 (B3GALT2)
Protein Structure
UniProt Annotation
Function Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues. {ECO:0000269PubMed:9417100, ECO:0000269PubMed:9582303}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in heart and brain. {ECO:0000269PubMed:9417100, ECO:0000269PubMed:9582303}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008378 galactosyltransferase activity
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0009312 oligosaccharide biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002659 Glycosyl transferase, family 31
PFAM PF01762
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43825
PhosphoSite PhosphoSite-O43825
TrEMBL
UniProt Splice Variant
Entrez Gene 8707
UniGene Hs.680660
RefSeq NP_003774
HUGO HGNC:917
OMIM 603018
CCDS CCDS1383
HPRD 04313
IMGT
EMBL AF288390 AK314116 AL390863 BC022507 CH471067 Y15014 Y15060
GenPept AAG60610 AAH22507 BAG36808 CAA75245 CAA75344 CAH71590 EAW91251

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca