InnateDB Protein
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IDBP-105522.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CFHR1
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Protein Name
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complement factor H-related 1
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Synonyms
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CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; H36-1; H36-2; HFL1; HFL2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000314299
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InnateDB Gene
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IDBG-409281 (CFHR1)
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Protein Structure
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Function |
Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. {ECO:0000269PubMed:23487775}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Expressed by the liver and secreted in plasma.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000436
Sushi/SCR/CCP
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PFAM |
PF00084
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PRINTS |
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PIRSF |
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SMART |
SM00032
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TIGRFAMs |
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Modification |
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SwissProt |
Q03591
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q6LBM9
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UniProt Splice Variant |
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Entrez Gene |
3078
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UniGene |
Hs.575869
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RefSeq |
NP_002104
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HUGO |
HGNC:4888
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OMIM |
134371
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CCDS |
CCDS1386
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HPRD |
00602
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IMGT |
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EMBL |
AK290830
AL049741
BC016755
BC107771
M65292
M65293
X56209
X56210
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GenPept |
AAA35946
AAA35947
AAH16755
AAI07772
BAF83519
CAA39666
CAA39667
CAB53063
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