Homo sapiens Protein: PTPRC | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-105615.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PTPRC | ||||||||||||||||||||||
Protein Name | protein tyrosine phosphatase, receptor type, C | ||||||||||||||||||||||
Synonyms | B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000306782 | ||||||||||||||||||||||
InnateDB Gene | IDBG-105609 (PTPRC) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Membrane {ECO:0000269PubMed:12676959}; Single-pass type I membrane protein {ECO:0000269PubMed:12676959}. Membrane raft {ECO:0000269PubMed:12676959}. Note=Colocalized with DPP4 in membrane rafts. | ||||||||||||||||||||||
Disease Associations | Severe combined immunodeficiency autosomal recessive T- cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. {ECO:0000269PubMed:11145714}. Note=The disease is caused by mutations affecting the gene represented in this entry.Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. {ECO:0000269PubMed:11101853}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. | ||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000242
Protein-tyrosine phosphatase, receptor/non-receptor type IPR000387 Protein-tyrosine/Dual specificity phosphatase IPR003595 Protein-tyrosine phosphatase, catalytic IPR003961 Fibronectin, type III IPR016335 Leukocyte common antigen IPR024739 Protein tyrosine phosphatase, receptor type, N-terminal IPR029021 Protein-tyrosine phosphatase-like |
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PFAM |
PF00102
PF00041 PF01108 PF12567 PF12453 |
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PRINTS |
PR00700
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PIRSF |
PIRSF002004
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SMART |
SM00194
SM00404 SM00060 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
PhosphoSite | PhosphoSite-P08575 | ||||||||||||||||||||||
TrEMBL | X6R433 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 5788 | ||||||||||||||||||||||
UniGene | Hs.654514 | ||||||||||||||||||||||
RefSeq | NP_563578 | ||||||||||||||||||||||
HUGO | HGNC:9666 | ||||||||||||||||||||||
OMIM | 151460 | ||||||||||||||||||||||
CCDS | CCDS1398 | ||||||||||||||||||||||
HPRD | 01050 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AL157402 AL355988 AY539683 AY539691 AY539699 | ||||||||||||||||||||||
GenPept | AAS46938 AAS46946 AAS46954 | ||||||||||||||||||||||