Homo sapiens Protein: PTPRC
Summary
InnateDB Protein IDBP-105615.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRC
Protein Name protein tyrosine phosphatase, receptor type, C
Synonyms B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200;
Species Homo sapiens
Ensembl Protein ENSP00000306782
InnateDB Gene IDBG-105609 (PTPRC)
Protein Structure
UniProt Annotation
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000269PubMed:12676959}; Single-pass type I membrane protein {ECO:0000269PubMed:12676959}. Membrane raft {ECO:0000269PubMed:12676959}. Note=Colocalized with DPP4 in membrane rafts.
Disease Associations Severe combined immunodeficiency autosomal recessive T- cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. {ECO:0000269PubMed:11145714}. Note=The disease is caused by mutations affecting the gene represented in this entry.Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. {ECO:0000269PubMed:11101853}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 72 [view]
Protein-Protein 72 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0045087 innate immune response (InnateDB)
GO:0050852 T cell receptor signaling pathway
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR016335 Leukocyte common antigen
IPR024739 Protein tyrosine phosphatase, receptor type, N-terminal
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PF00041
PF01108
PF12567
PF12453
PRINTS PR00700
PIRSF PIRSF002004
SMART SM00194
SM00404
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-P08575
TrEMBL X6R433
UniProt Splice Variant
Entrez Gene 5788
UniGene Hs.654514
RefSeq NP_563578
HUGO HGNC:9666
OMIM 151460
CCDS CCDS1398
HPRD 01050
IMGT
EMBL AL157402 AL355988 AY539683 AY539691 AY539699
GenPept AAS46938 AAS46946 AAS46954