InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF14

Summary

InnateDB Protein

IDBP-105660.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF14

Protein Name

kinesin family member 14

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356319

InnateDB Gene

IDBG-105656 (KIF14)

Protein Structure

UniProt Annotation

Function

Plays an essential role in cytokinesis. {ECO:0000269PubMed:16431929, ECO:0000269PubMed:16648480}.

Subcellular Localization

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Nuclear localization observed during interphase in PubMed:16431929 or triggered by entry into mitosis in PubMed:16648480. Cytoplasmic in interphase (PubMed:16648480) and metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring. {ECO:0000269PubMed:16431929, ECO:0000269PubMed:16648480}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0030165	PDZ domain binding

Biological Process

GO:0007018	microtubule-based movement
GO:0008152	metabolic process
GO:0030155	regulation of cell adhesion
GO:0030334	regulation of cell migration
GO:0032487	regulation of Rap protein signal transduction
GO:0033624	negative regulation of integrin activation
GO:0034446	substrate adhesion-dependent cell spreading
GO:0045184	establishment of protein localization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000253 Forkhead-associated (FHA) domain
IPR001752 Kinesin, motor domain
IPR008984 SMAD/FHA domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00498
PF00225

PRINTS

PR00380

PIRSF

SMART

SM00240
SM00129

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt