InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BTG2

Summary

InnateDB Protein

IDBP-105949.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BTG2

Protein Name

BTG family, member 2

Synonyms

PC3; TIS21;

Species

Homo sapiens

Ensembl Protein

ENSP00000290551

InnateDB Gene

IDBG-105945 (BTG2)

Protein Structure

UniProt Annotation

Function

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. {ECO:0000250, ECO:0000269PubMed:12771185, ECO:0000269PubMed:15788397, ECO:0000269PubMed:18337750, ECO:0000269PubMed:18773938, ECO:0000269PubMed:23236473}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006479	protein methylation
GO:0006974	cellular response to DNA damage stimulus
GO:0008285	negative regulation of cell proliferation
GO:0008306	associative learning
GO:0009612	response to mechanical stimulus
GO:0009952	anterior/posterior pattern specification
GO:0010033	response to organic substance
GO:0010243	response to organonitrogen compound
GO:0014070	response to organic cyclic compound
GO:0017148	negative regulation of translation
GO:0021542	dentate gyrus development
GO:0021954	central nervous system neuron development
GO:0030182	neuron differentiation
GO:0031175	neuron projection development
GO:0035914	skeletal muscle cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0043524	negative regulation of neuron apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051602	response to electrical stimulus
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:2000178	negative regulation of neural precursor cell proliferation