InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTSE

Summary

InnateDB Protein

IDBP-106220.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSE

Protein Name

cathepsin E

Synonyms

CATE;

Species

Homo sapiens

Ensembl Protein

ENSP00000350911

InnateDB Gene

IDBG-106216 (CTSE)

Protein Structure

UniProt Annotation

Function

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. {ECO:0000269PubMed:8765029}.

Subcellular Localization

Endosome {ECO:0000269PubMed:7983070}. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.

Disease Associations

Tissue Specificity

Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B- lymphocytes. {ECO:0000269PubMed:11322887, ECO:0000269PubMed:1370478, ECO:0000269PubMed:8765029}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006508	proteolysis
GO:0007586	digestion
GO:0016540	protein autoprocessing
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II