Version 5.4
Homo sapiens Protein: CTSE
Summary
InnateDB Protein IDBP-106222.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSE
Protein Name cathepsin E
Synonyms CATE;
Species Homo sapiens
Ensembl Protein ENSP00000353350
InnateDB Gene IDBG-106216 (CTSE)
Protein Structure
UniProt Annotation
Function May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. {ECO:0000269PubMed:8765029}.
Subcellular Localization Endosome {ECO:0000269PubMed:7983070}. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
Disease Associations
Tissue Specificity Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B- lymphocytes. {ECO:0000269PubMed:11322887, ECO:0000269PubMed:1370478, ECO:0000269PubMed:8765029}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007586 digestion
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005768 endosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001461 Aspartic peptidase
IPR012848 Aspartic peptidase, N-terminal
IPR021109 Aspartic peptidase domain
PFAM PF00026
PF07966
PRINTS PR00792
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P14091
PhosphoSite PhosphoSite-P14091
TrEMBL B4DNU8
UniProt Splice Variant
Entrez Gene 1510
UniGene Hs.644082
RefSeq NP_683865
HUGO HGNC:2530
OMIM 116890
CCDS CCDS73012
HPRD 00294
IMGT
EMBL AJ250716 AJ250717 AK292057 AK298069 BC042537 BX571818 CH471067 J05036 M84413 M84417 M84418 M84419 M84420 M84421 M84422 M84424
GenPept AAA52130 AAA52300 AAH42537 BAF84746 BAG60360 CAB82849 CAB82850 CAH73264 CAH73265 EAW91592 EAW91593

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca