Version 5.4
Homo sapiens Protein: G0S2
Summary
InnateDB Protein IDBP-106428.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol G0S2
Protein Name G0/G1switch 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355996
InnateDB Gene IDBG-106426 (G0S2)
Protein Structure
UniProt Annotation
Function Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. {ECO:0000269PubMed:19706769}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:19706769}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver. {ECO:0000269PubMed:19706769}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0097191 extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005811 lipid particle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P27469
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 50486
UniGene
RefSeq NP_056529
HUGO HGNC:30229
OMIM 614447
CCDS CCDS1488
HPRD 09968
IMGT
EMBL AL031316 BC009694 BT007101 CH471100 CR542179 CR542193 M69199 M72885
GenPept AAA58966 AAB04044 AAH09694 AAP35765 CAB40150 CAG46976 CAG46990 EAW93447

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca