InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNH1

Summary

InnateDB Protein

IDBP-106486.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNH1

Protein Name

potassium voltage-gated channel, subfamily H (eag-related), member 1

Synonyms

EAG; EAG1; h-eag; Kv10.1;

Species

Homo sapiens

Ensembl Protein

ENSP00000271751

InnateDB Gene

IDBG-106484 (KCNH1)

Protein Structure

UniProt Annotation

Function

Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:21559285}; Multi-pass membrane protein {ECO:0000269PubMed:21559285}. Nucleus inner membrane {ECO:0000269PubMed:21559285}; Multi-pass membrane protein {ECO:0000269PubMed:21559285}. Note=Perinuclear KCNH1 is located to NPC-free islands.

Disease Associations

Tissue Specificity

Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000155	phosphorelay sensor kinase activity
GO:0004871	signal transducer activity
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006355	regulation of transcription, DNA-templated
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007520	myoblast fusion
GO:0023014	signal transduction by phosphorylation
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005637	nuclear inner membrane
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR000595 Cyclic nucleotide-binding domain
IPR000700 PAS-associated, C-terminal
IPR001610 PAC motif
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR003949 Potassium channel, voltage-dependent, EAG
IPR003967 Potassium channel, voltage-dependent, ERG
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain
IPR013767 PAS fold
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF13188
PF13426
PF00027
PF00520
PF07885
PF00989

PRINTS

PR01463
PR01464
PR01470

PIRSF

SMART

SM00091
SM00100
SM00086

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt