Homo sapiens Protein: PROX1
InnateDB Protein IDBP-106633.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROX1
Protein Name prospero homeobox 1
Species Homo sapiens
Ensembl Protein ENSP00000355925
InnateDB Gene IDBG-106631 (PROX1)
Protein Structure
UniProt Annotation
Subcellular Localization
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 2 [view]
Protein-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0050692 DBD domain binding
GO:0050693 LBD domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001709 cell fate determination
GO:0001822 kidney development
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001945 lymph vessel development
GO:0001946 lymphangiogenesis
GO:0002088 lens development in camera-type eye
GO:0002089 lens morphogenesis in camera-type eye
GO:0002194 hepatocyte cell migration
GO:0006366 transcription from RNA polymerase II promoter
GO:0007420 brain development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0010595 positive regulation of endothelial cell migration
GO:0021516 dorsal spinal cord development
GO:0021542 dentate gyrus development
GO:0021707 cerebellar granule cell differentiation
GO:0021915 neural tube development
GO:0030240 skeletal muscle thin filament assembly
GO:0030324 lung development
GO:0030910 olfactory placode formation
GO:0031016 pancreas development
GO:0031667 response to nutrient levels
GO:0043049 otic placode formation
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045071 negative regulation of viral genome replication
GO:0045446 endothelial cell differentiation
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046619 optic placode formation involved in camera-type eye formation
GO:0048839 inner ear development
GO:0048845 venous blood vessel morphogenesis
GO:0055005 ventricular cardiac myofibril assembly
GO:0055009 atrial cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060042 retina morphogenesis in camera-type eye
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060214 endocardium formation
GO:0060298 positive regulation of sarcomere organization
GO:0060412 ventricular septum morphogenesis
GO:0060414 aorta smooth muscle tissue morphogenesis
GO:0060421 positive regulation of heart growth
GO:0060836 lymphatic endothelial cell differentiation
GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment
GO:0070309 lens fiber cell morphogenesis
GO:0070365 hepatocyte differentiation
GO:0070858 negative regulation of bile acid biosynthetic process
GO:0072574 hepatocyte proliferation
GO:0097150 neuronal stem cell maintenance
GO:1901978 positive regulation of cell cycle checkpoint
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000979 positive regulation of forebrain neuron differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
InterPro IPR009057 Homeodomain-like
IPR023082 Homeo-prospero domain
PFAM PF05044
Post-translational Modifications
SwissProt Q92786
PhosphoSite PhosphoSite-Q92786
UniProt Splice Variant
Entrez Gene 5629
UniGene Hs.743536
RefSeq NP_001257545
OMIM 601546
HPRD 03330
EMBL AC011700 AK290176 AK298182 AL606537 BC024201 CH471100 U44060
GenPept AAC50656 AAH24201 BAF82865 BAG60453 CAI15309 EAW93360