InnateDB Protein
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IDBP-106893.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DEGS1
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Protein Name
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degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)
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Synonyms
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DEGS; DEGS-1; Des-1; DES1; FADS7; MLD;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000316476
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InnateDB Gene
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IDBG-106891 (DEGS1)
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Protein Structure
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Function |
Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). {ECO:0000269PubMed:11937514}.
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Subcellular Localization |
Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:9188692}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
|
Protein-Protein |
7
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0009055
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electron carrier activity
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GO:0016705
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oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005804
Fatty acid desaturase, type 1
IPR011388
Sphingolipid delta4-desaturase
IPR013866
Sphingolipid delta4-desaturase, N-terminal
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PFAM |
PF00487
PF08557
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PRINTS |
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PIRSF |
PIRSF017228
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O15121
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PhosphoSite |
PhosphoSite-O15121
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TrEMBL |
A0A024R3P1
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UniProt Splice Variant |
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Entrez Gene |
8560
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UniGene |
Hs.299878
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RefSeq |
NP_003667
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HUGO |
HGNC:13709
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OMIM |
615843
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CCDS |
CCDS1540
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HPRD |
13133
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IMGT |
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EMBL |
AF002668
AF466375
AY423730
BC000961
CH471098
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GenPept |
AAB62238
AAH00961
AAM12531
AAS00493
EAW69711
EAW69712
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