Version 5.4
Homo sapiens Protein: ACBD3
Summary
InnateDB Protein IDBP-107014.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACBD3
Protein Name acyl-CoA binding domain containing 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355777
InnateDB Gene IDBG-107012 (ACBD3)
Protein Structure
UniProt Annotation
Function Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Also mitochondrial (via its interaction with PBR). {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous, with highest expression in testis and ovary. {ECO:0000269PubMed:11590181}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0005515 protein binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006810 transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000582 Acyl-CoA-binding protein, ACBP
IPR009038 GOLD
PFAM PF00887
PF01105
PF13897
PRINTS PR00689
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H3P7
PhosphoSite PhosphoSite-Q9H3P7
TrEMBL A0A024R3P9
UniProt Splice Variant
Entrez Gene 64746
UniGene Hs.520207
RefSeq NP_073572
HUGO HGNC:15453
OMIM 606809
CCDS CCDS1551
HPRD 08432
IMGT
EMBL AB043587 AK025520 AK314468 AL592045 AY150218 BC034563 BC045533 BC060792 CH471098
GenPept AAH34563 AAH45533 AAH60792 AAN60219 BAB15159 BAB20592 BAG37076 CAH71922 EAW69775 EAW69776

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca