Version 5.4
Homo sapiens Protein: LIN9
Summary
InnateDB Protein IDBP-107029.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIN9
Protein Name lin-9 homolog (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000329102
InnateDB Gene IDBG-107021 (LIN9)
Protein Structure
UniProt Annotation
Function Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269PubMed:15538385, ECO:0000269PubMed:16730350}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000269PubMed:15538385, ECO:0000269PubMed:16730350}. Note=Found in perinucleolar structures. Associated with chromatin.
Disease Associations
Tissue Specificity Expressed in thymus and testis. {ECO:0000269PubMed:15538385}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006351 transcription, DNA-templated
GO:0007049 cell cycle
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005654 nucleoplasm
GO:0017053 transcriptional repressor complex
Protein Structure and Domains
PDB ID
InterPro IPR010561 Protein LIN-9/Protein ALWAYS EARLY
PFAM PF06584
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5TKA1
PhosphoSite PhosphoSite-Q5TKA1
TrEMBL B1B047
UniProt Splice Variant
Entrez Gene 286826
UniGene Hs.602486
RefSeq NP_775106
HUGO HGNC:30830
OMIM 609375
CCDS CCDS1553
HPRD 13990
IMGT
EMBL AF190323 AF190324 AK126177 AL359742 AY786184 BC043444 BC045625 BX284931 BX537869
GenPept AAH43444 AAH45625 AAQ13710 AAQ13711 AAV41873 BAC86475 CAD97871

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca