InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOMM20

Summary

InnateDB Protein

IDBP-107526.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOMM20

Protein Name

translocase of outer mitochondrial membrane 20 homolog (yeast)

Synonyms

MAS20; MOM19; TOM20;

Species

Homo sapiens

Ensembl Protein

ENSP00000355566

InnateDB Gene

IDBG-107524 (TOMM20)

Protein Structure

UniProt Annotation

Function

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO:0051082	unfolded protein binding

Biological Process

GO:0006605	protein targeting
GO:0006626	protein targeting to mitochondrion
GO:0006886	intracellular protein transport
GO:0044267	cellular protein metabolic process
GO:0071806	protein transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005741	mitochondrial outer membrane
GO:0005742	mitochondrial outer membrane translocase complex
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002056 Protein import receptor MAS20-related
IPR022422 Protein import receptor MAS20, metazoan
IPR023392 Mitochondrial outer membrane translocase complex, subunit Tom20 domain

PFAM

PF02064

PRINTS

PR00351
PR01989

PIRSF

PIRSF037707

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt