InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GGPS1

Summary

InnateDB Protein

IDBP-107545.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GGPS1

Protein Name

geranylgeranyl diphosphate synthase 1

Synonyms

GGPPS; GGPPS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000351852

InnateDB Gene

IDBG-107543 (GGPS1)

Protein Structure

UniProt Annotation

Function

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Abundantly expressed in testis. Found in other tissues to a lower extent.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004161	dimethylallyltranstransferase activity
GO:0004311	farnesyltranstransferase activity
GO:0004337	geranyltranstransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0006720	isoprenoid metabolic process
GO:0008299	isoprenoid biosynthetic process
GO:0033384	geranyl diphosphate biosynthetic process
GO:0033386	geranylgeranyl diphosphate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0045337	farnesyl diphosphate biosynthetic process