Version 5.4
Homo sapiens Protein: HEATR1
Summary
InnateDB Protein IDBP-107629.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HEATR1
Protein Name HEAT repeat containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355541
InnateDB Gene IDBG-107627 (HEATR1)
Protein Structure
UniProt Annotation
Function Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:12429849}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006364 rRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro IPR012954 BP28, C-terminal domain
IPR016024 Armadillo-type fold
IPR022125 U3 small nucleolar RNA-associated protein 10
PFAM PF08146
PF12397
PRINTS
PIRSF
SMART SM01036
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H583
PhosphoSite PhosphoSite-Q9H583
TrEMBL Q6P664
UniProt Splice Variant
Entrez Gene 55127
UniGene Hs.708114
RefSeq NP_060542
HUGO HGNC:25517
OMIM
CCDS CCDS31066
HPRD 17569
IMGT
EMBL AK001221 AL359921 AX067150 BC062442 BC065205
GenPept AAH62442 AAH65205 BAA91564 CAC26776 CAI13775

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca