Homo sapiens Protein: MT-ND4
InnateDB Protein IDBP-108123.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MT-ND4
Protein Name mitochondrially encoded NADH dehydrogenase 4
Synonyms MTND4;
Species Homo sapiens
Ensembl Protein ENSP00000354961
InnateDB Gene IDBG-108121 (MT-ND4)
Protein Structure
UniProt Annotation
Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.
Disease Associations Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. {ECO:0000269PubMed:1959931, ECO:0000269PubMed:3201231, ECO:0000269PubMed:9452107}. Note=The disease is caused by mutations affecting the gene represented in this entry.Leber hereditary optic neuropathy with dystonia (LDYT) [MIM:500001]: Part of a spectrum of Leber hereditary optic neuropathy. It is characterized by the association of optic atrophy and central vision loss with dystonia. {ECO:0000269PubMed:8644732}. Note=The disease is caused by mutations affecting the gene represented in this entry.Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS) [MIM:540000]: Genetically heterogeneous disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness. {ECO:0000269PubMed:1323207}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0022904 respiratory electron transport chain
GO:0042773 ATP synthesis coupled electron transport
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
GO:0016021 integral component of membrane
Protein Structure and Domains
InterPro IPR000260 NADH:ubiquinone oxidoreductase, chain 4, N-terminal
IPR001750 NADH:ubiquinone/plastoquinone oxidoreductase
IPR003918 NADH:ubiquinone oxidoreductase
IPR010227 NADH-quinone oxidoreductase, chain M/4
PFAM PF01059
Post-translational Modifications
SwissProt P03905
PhosphoSite PhosphoSite-P03905
UniProt Splice Variant
Entrez Gene 4538
UniGene Hs.717409
RefSeq YP_003024035
OMIM 516003
EMBL AB196727 AF346963 AF346964 AF346966 AF346967 AF346968 AF346969 AF346971 AF346974 AF346975 AF346977 AF346978 AF346980 AF346981 AF346982 AF346985 AF346986 AF346987 AF346989 AF346990 AF346993 AF346994 AF346996 AF346997 AF347000 AF347002 AF347003 AF347004 AF347005 AF347006 AF347007 AF347010 AF347011 AF347012 AF347013 AF347014 AF347015 AF465942 AP010971 AP010972 AP010973 AP010974 AP010975 AP010976 AP010977 AP010978 AP010979 AP010980 AP010981 AP010982 AP010983 AP010984 AP010985 AP010989 AP010990 AP010991 AP010992 AP010993 AP010994 AP010995 AP010996 AP011000 AP011001 AP011002 AP011003 AP011004 AP011005 AP011006 AP011007 AP011008 AP011010 AP011011 AP011013 AP011014 AP011015 AP011016 AP011017 AP011018 AP011020 AP011022 AP011024 AP011025 AP011026 AP011027 AP011028 AP011029 AP011030 AP011031 AP011032 AP011033 AP011036 AP011037 AP011038 AP011039 AP011040 AP011041 AP011042 AP011043 AP011044 AP011045 AP011046 AP011047 AP011048 AP011049 AP011050 AP011051 AP011052 AP011053 AP011054 AP011055 AP011056 AP011057 AP011058 AP011059 AP012356 AP012361 AP013142 AY289051 AY289052 AY289055 AY289056 AY289058 AY289059 AY289060 AY289061 AY289062 AY289063 AY289065 AY289068 AY289069 AY289070 AY289071 AY289073 AY289074 AY289075 AY289076 AY289077 AY289079 AY289080 AY289081 AY289082 AY289083 AY289084 AY289085 AY289087 AY289088 AY289090 AY289091 AY289092 AY289093 AY289094 AY289095 AY289096 AY289097 AY289098 AY289099 AY289100 AY289101 AY289102 AY495090 AY495091 AY495092 AY495093 AY495094 AY495095 AY495096 AY495097 AY495098 AY495099 AY495100 AY495101 AY495102 AY495103 AY495104 AY495106 AY495107 AY495108 AY495109 AY495110 AY495111 AY495112 AY495113 AY495114 AY495115 AY495116 AY495117 AY495118 AY495119 AY495120 AY495121 AY495122 AY495123 AY495124 AY495125 AY495126 AY495127 AY495128 AY495129 AY495130 AY495131 AY495132 AY495133 AY495134 AY495135 AY495136 AY495137 AY495138 AY495139 AY495140 AY495141 AY495142 AY495143 AY495144 AY495145 AY495146 AY495147 AY495148 AY495149 AY495150 AY495151 AY495152 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AY495329 AY495330 DQ437577 DQ654094 DQ654095 DQ654096 DQ654097 DQ654098 DQ654099 DQ654100 DQ654101 DQ654102 DQ654103 DQ654104 DQ654105 DQ654106 DQ654107 DQ654108 DQ654109 DQ654110 DQ654111 DQ654112 DQ654113 DQ654114 DQ654115 DQ654116 DQ654117 DQ654118 DQ654119 DQ654120 DQ654121 DQ654122 DQ654123 DQ654124 DQ654125 DQ654126 DQ654127 DQ654128 DQ654129 DQ654130 DQ654131 DQ654132 DQ654133 DQ654134 DQ654135 DQ654136 DQ654137 DQ654138 DQ654139 DQ654140 DQ654141 DQ654142 DQ654143 DQ654144 DQ654145 DQ654146 DQ654147 DQ654148 DQ654149 DQ654150 DQ654151 DQ654152 DQ654153 DQ654154 DQ654155 DQ654156 DQ654157 DQ654158 DQ654159 DQ654160 DQ654161 DQ654162 DQ654163 DQ654164 DQ654165 DQ654166 DQ654167 DQ654168 DQ654169 DQ654170 DQ654171 DQ654172 DQ654173 DQ654174 DQ654175 DQ654176 DQ654177 DQ654178 DQ654179 DQ654180 DQ654181 DQ654182 DQ654183 DQ654184 DQ654185 DQ654186 DQ654187 DQ654188 DQ654189 DQ654190 DQ654191 DQ654192 DQ654193 DQ654194 DQ654195 DQ654196 DQ654197 DQ654198 DQ654199 DQ654200 DQ654201 DQ654202 DQ654203 DQ654204 DQ654205 DQ654206 DQ654207 DQ654208 DQ654209 DQ654210 DQ654211 DQ654212 DQ654213 DQ654214 DQ654215 DQ654216 DQ654217 DQ654218 DQ654219 DQ654220 DQ654221 DQ654222 DQ654223 DQ654224 DQ654225 DQ654226 DQ654227 DQ654228 DQ654229 DQ654230 DQ654231 DQ654232 DQ654233 DQ654234 DQ654235 DQ654236 DQ654237 DQ654238 DQ654239 DQ654240 DQ654241 DQ654242 DQ654243 DQ654244 DQ654245 DQ654246 DQ654247 DQ654248 DQ654249 DQ654250 DQ654251 DQ654252 DQ654253 DQ654254 DQ654255 DQ654256 DQ654257 DQ654258 DQ654259 DQ654260 DQ654261 DQ654262 DQ654263 DQ654264 DQ654265 DQ654266 DQ654267 DQ654268 DQ654269 DQ654270 DQ654271 DQ654272 DQ654273 DQ654274 DQ654275 DQ654276 DQ654277 DQ654278 DQ654279 DQ654280 DQ654281 DQ654282 DQ654283 DQ654284 DQ654285 DQ654286 DQ654287 DQ654288 DQ654289 DQ654290 DQ654291 DQ654292 DQ654293 DQ654294 DQ654295 DQ654296 DQ654297 DQ654298 DQ654299 DQ654300 DQ654301 DQ654302 DQ654303 DQ654304 DQ654305 DQ654306 DQ654307 DQ654308 DQ654309 DQ654310 DQ654311 DQ654312 DQ654313 DQ654314 DQ654315 DQ654316 DQ654317 DQ654318 DQ654319 DQ654320 DQ654321 DQ654322 DQ654323 DQ654324 DQ654325 DQ654326 DQ654327 DQ654328 DQ654329 DQ654330 DQ654331 DQ654332 DQ654333 DQ654334 DQ654335 DQ654336 DQ654337 DQ654338 DQ654339 DQ654340 DQ654341 DQ654342 DQ654343 DQ654344 DQ654345 DQ654346 DQ654347 DQ654348 DQ654349 DQ654350 DQ654351 DQ654352 DQ654353 DQ654354 DQ654355 DQ654356 DQ654357 DQ654358 DQ654359 DQ654360 DQ654361 DQ654362 DQ654363 DQ654364 DQ654365 DQ654366 DQ654367 DQ654368 DQ654369 DQ654370 DQ654371 DQ654372 DQ654373 DQ654374 DQ654375 DQ654376 DQ654377 DQ654378 DQ654379 DQ654380 DQ654381 DQ654382 DQ654383 DQ654384 DQ654385 DQ654386 DQ654387 DQ654388 DQ654389 DQ654390 DQ654391 DQ654392 DQ654393 GQ863626 GQ863627 GQ863628 GQ863629 GQ863630 GQ863631 GQ863632 GQ863633 GQ863634 GU186087 GU186088 GU397542 GU397543 J01415 JQ701741 JQ731598 JQ731599 JQ731600 JQ731601 JX152783 JX152784 JX152785 JX152786 JX152787 JX152788 JX152789 JX152790 JX152791 JX152792 JX152793 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