Version 5.4
Homo sapiens Protein: CPVL
Summary
InnateDB Protein IDBP-10846.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPVL
Protein Name carboxypeptidase, vitellogenic-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265394
InnateDB Gene IDBG-10844 (CPVL)
Protein Structure
UniProt Annotation
Function May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004185 serine-type carboxypeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001563 Peptidase S10, serine carboxypeptidase
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00450
PRINTS PR00724
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H3G5
PhosphoSite PhosphoSite-Q9H3G5
TrEMBL Q75MM4
UniProt Splice Variant
Entrez Gene 54504
UniGene Hs.739082
RefSeq NP_112601
HUGO HGNC:14399
OMIM 609780
CCDS CCDS5419
HPRD 07479
IMGT
EMBL AC004593 AC005162 AC005232 AC007096 AF106704 AF282617 AK075433 AY358549 BC016838 CH236948 CH471073
GenPept AAC23787 AAG14348 AAG37991 AAH16838 AAQ88913 AAS07545 BAC11618 EAL24207 EAW93914 EAW93916

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca