Version 5.4
Homo sapiens Protein: PARVG
Summary
InnateDB Protein IDBP-10938.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARVG
Protein Name parvin, gamma
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349378
InnateDB Gene IDBG-10936 (PARVG)
Protein Structure
UniProt Annotation
Function Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. {ECO:0000250}.
Subcellular Localization Cell junction, focal adhesion. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Constituent of focal adhesions. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed predominantly in lymphoid organs, including spleen, thymus, lymph node, bone marrow and peripheral blood leukocytes and moderately in the digestive tract, including stomach, duodenum, jejunum, ileum, ileocecum and appendix, as well as in lung and liver. Also expressed in tumors, but at a lower level than in the corresponding normal tissues. {ECO:0000269PubMed:11722847}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007160 cell-matrix adhesion
GO:0031532 actin cytoskeleton reorganization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
Protein Structure and Domains
PDB ID
InterPro IPR001715 Calponin homology domain
PFAM PF00307
PRINTS
PIRSF
SMART SM00033
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HBI0
PhosphoSite PhosphoSite-Q9HBI0
TrEMBL B0QYM9
UniProt Splice Variant
Entrez Gene 64098
UniGene
RefSeq
HUGO HGNC:14654
OMIM 608122
CCDS
HPRD 16285
IMGT
EMBL AF237772 AK293360 AK307294 AL031595 AL355092 AL590887 BC034406 CR456480
GenPept AAG27174 AAH34406 BAG56876 CAB90188 CAC37414 CAG30366 CAI22314

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca